化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylpiperidine → 1-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylpiperidine | HCID 69381 | — |
| 反応物 | 4-Chloro-2-fluoro-1-nitrobenzene | HCID 69691 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine | HCID 58638501 | 99.1% |
反応手順
The procedure of Example 4, step (a) was followed using 0.950 g (5.43 mmol) of 4-chloro-2-fluoronitrobenzene and 1.93 mL (16.3 mmol) of 4-methylpiperidine in 10 mL of EtOH to afford 1.37 g (99%) of the title compound as an orange oil which crystallized on standing: Mass spectrum (ESI, m/z): Calcd. for C12H15ClN2O2, 255.1 (M+H), found 255.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07705042B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-753252e58d0c4122b412b699fcd85a87 |
| 出典メモ | uspto-grants-2010_04 |