Piperazine → 1-[3-(4-Methyl-piperidin-1-yl)-4-nitro-phenyl]-piperazine

HRID 646862

反応式

HRID 646862 の反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-:17])=[O:16])=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH3:14])[CH2:10][CH2:9]2)[CH:7]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>CO.ClCCl>[CH3:14][CH:11]1[CH2:12][CH2:13][N:8]([C:6]2[CH:7]=[C:2]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:3]=[CH:4][C:5]=2[N+:15]([O-:17])=[O:16])[CH2:9][CH2:10]1

参加物

4

反応物 2

HCID 4837PiperazineHCID 586385011-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine

生成物 1

HCID 586385501-[3-(4-Methyl-piperidin-1-yl)-4-nitro-phenyl]-piperazine収率 94%

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The procedure of Example 4, step (b) was followed using 460 mg (1.81 mmol) of 1-(5-chloro-2-nitro-phenyl)-4-methyl-piperidine (as prepared in the Example 12, step (a)) and 3.12 g (36.2 mmol) of piperazine for 24 h to afford, after chromatography on a 20-g silica SPE column with 0-10% MeOH-dichloromethane, 518 mg (94%) of the title compound as an orange resin: Mass spectrum (ESI, m/z): Calcd. for C16H24N4O2, 305.2 (M+H), found 305.1.

後処理

  1. customto afford

出典と根拠

ORDレコード
ord-f7f76e6e12184c7b9f2fa13578520345
出典データセット
uspto-grants-2010_04
特許番号
US07705042B2

関連ノート

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