3-(Trifluoromethyl)phenol → 2-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

HRID 64694

反応式

HRID 64694 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[K+].Cl[CH2:15][CH:16]([OH:20])[CH2:17][CH2:18][Cl:19]>O.C(O)(C)C>[Cl:19][CH2:18][CH2:17][CH:16]([OH:20])[CH2:15][O:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1

参加物

6

反応物 3

HCID 73763-(Trifluoromethyl)phenolHCID 14797Potassium HydroxideHCID 170211,4-Dichloro-2-butanol

生成物 1

HCID 131203482-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 3776Isopropanol溶媒

反応条件

温度
65 °C

実験手順

To a mixture of 0.5 mole (75 g.) of m-trifluoromethylphenol, 1 mole (56 g.) of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 0.6 mole (84 g.) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr., mixed with 2 liters of water, and extracted with 400 ml. of isopropyl ether. The ether extract was washed with 0.5N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm. solidified at room temperature and melted at 50°-52° C.

後処理

  1. customThe resulting reaction mixture
  2. extractionextracted with 400 ml
  3. extractionThe ether extract
  4. washwas washed with 0.5N sodium hydroxide
  5. dry with materialwith water, dried over sodium sulfate
  6. distillationdistilled under reduced pressure
  7. distillationThe distillate which was collected at 120°-124° C./0.01 mm
  8. customsolidified at room temperature

出典と根拠

ORDレコード
ord-f451d76dd022479d86c4d6ad57a6b1ae
出典データセット
uspto-grants-1986_09
特許番号
US04609735

関連ノート

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