Triethylamine → Methyl 3-ethoxy-2-(ethoxyimino)-3-iminopropanoate

HRID 647113

反応式

HRID 647113 の反応式
F[B-](F)(F)F.[CH2:6]([O+](CC)CC)[CH3:7].[F-].[C:14]([C:17](=[N:22][O:23][CH2:24][CH3:25])[C:18]([O:20][CH3:21])=[O:19])(=[O:16])[NH2:15].C(N(CC)CC)C>C(Cl)Cl.O>[NH:15]=[C:14]([O:16][CH2:6][CH3:7])[C:17](=[N:22][O:23][CH2:24][CH3:25])[C:18]([O:20][CH3:21])=[O:19]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 28179Fluoride IonHCID 2723982Triethyloxonium tetrafluoroborateHCID 53690437Methyl 3-amino-2-(ethoxyimino)-3-oxopropanoate

生成物 1

HCID 53663360Methyl 3-ethoxy-2-(ethoxyimino)-3-iminopropanoate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of Meerwein reagent (triethyloxonium tetrafluoroborate) {prepared from bron fluoride etherate (2.84 g) by a method of Org. Syn., 46, 113 (1966)} in methylene chloride (30 ml) was added methyl 2-carbamoyl-2-ethoxyiminoacetate (syn isomer, 2.6 g) and the mixture was stirred for 18 hours at room temperature. The reaction mixture was cooled in an ice-bath and triethylamine (3 g) was added thereto, followed by an addition of water (20 ml). The organic layer was separated out, dried over magnesium sulfate and evaporated to give crude methyl 3-imino-3-ethoxy-2-ethoxyiminopropionate (syn isomer) (5.0 g) as an oil. ##STR15##

後処理

  1. temperatureThe reaction mixture was cooled in an ice-bath
  2. customThe organic layer was separated out
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-c2c14045175f4522914e930aa28b5372
出典データセット
uspto-grants-1983_10
特許番号
US04407798

関連ノート

読み込み中…