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Ethyl Acetate → 16beta-Ethyl-17beta-(3-oxobutyryl)oxyacetoxy-4-estren-3-one

HRID 64726
ノート
印刷プレビュー

反応式

HRID 64726 の反応式
[CH2:1]([C@H:3]1[CH2:8][C@H:7]2[C@H:9]3[C@H:18]([CH2:19][CH2:20][C@:5]2([CH3:6])[C@H:4]1[O:22][C:23](=[O:26])[CH2:24][OH:25])[C@@H:17]1[C:12](=[CH:13][C:14](=[O:21])[CH2:15][CH2:16]1)[CH2:11][CH2:10]3)[CH3:2].C([O-])(=O)C.[Na+].[CH2:32]=[C:33]1[O:37][C:35](=[O:36])[CH2:34]1.C(OCC)(=O)C>ClCCl>[CH2:1]([C@H:3]1[CH2:8][C@H:7]2[C@H:9]3[C@H:18]([CH2:19][CH2:20][C@:5]2([CH3:6])[C@H:4]1[O:22][C:23](=[O:26])[CH2:24][O:25][C:35](=[O:36])[CH2:34][C:33](=[O:37])[CH3:32])[C@@H:17]1[C:12](=[CH:13][C:14](=[O:21])[CH2:15][CH2:16]1)[CH2:11][CH2:10]3)[CH3:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 12661DiketeneHCID 517045Sodium AcetateHCID 7046644116beta-Ethyl-17beta-glycoloyloxy-4-estren-3-one

生成物 1

HCID 7046732716beta-Ethyl-17beta-(3-oxobutyryl)oxyacetoxy-4-estren-3-one

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒

実験手順

In 30 ml of dichloromethane is dissolved 0.8 g of 16β-ethyl-17β-glycoloyloxy-4-estren-3-one, and 0.24 g of anhydrous sodium acetate and 0.3 ml of diketene are added. The mixture is refluxed for 4 hours. After cooling, 100 ml of ethyl acetate is added and the mixture is washed with water and saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent is then distilled off under reduced pressure and the residue is subjected to column chromatography. Following serial passage of 400 ml of diisopropyl ether and 400 ml of diisopropyl ether-ethyl acetate (10:1), elution is carried out with 600 ml of isopropyl ether-ethyl acetate (2:3). The eluate is evaporated under reduced pressure to remove the solvent, giving 1.0 g of the above-identified compound as a light-yellow viscous oil.

後処理

  1. additionare added
  2. temperatureThe mixture is refluxed for 4 hours
  3. temperatureAfter cooling
  4. washthe mixture is washed with water and saturated aqueous sodium chloride solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent is then distilled off under reduced pressure
  7. washpassage of 400 ml of diisopropyl ether and 400 ml of diisopropyl ether-ethyl acetate (10:1), elution
  8. customThe eluate is evaporated under reduced pressure
  9. customto remove the solvent

出典と根拠

ORDレコード
ord-a12a091f133c40afb685201a87e3a710
出典データセット
uspto-grants-1986_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04609650

反応ノート

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