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Potassium Carbonate → 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenol | HCID 12940613 | — |
| 反応物 | Methyl 4-bromo-3-methoxypent-2-enoate | HCID 54279858 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid | HCID 53860348 | — |
反応手順
A mixture of 4-(2-chloro-4-trifluoromethylphenoxy) phenol (6.9 mmol.), methyl 4-bromo-3-methoxy-2-pentenoate (8.9 mmol.) and potassium carbonate (1.5 equis.) in acetone (15 ml.) is refluxed for 48 hours. After filtration, the filtrate was concentrated and the residue chromatographed on silica gel using 20% ethylacetate/hexane to give the methyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04408076 |
| 出典データセット | uspto-grants-1983_10 |
| ORD ID | ord-493aa7b9e12743a5bfd74929eaef950c |
| 出典メモ | uspto-grants-1983_10 |