関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 6-Chloro-3H-isobenzofuran-1-one | HCID 7174165 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Chloro-2-carboxyphenylacetonitrile | HCID 12603204 | 73.3% |
反応手順
A mixture of 6-chlorophthalide (2.0 g) and potassium cyanide (2.0 g) was stirred at a temperature of 180° C. for a period of 4 hours. The solid was cooled, dissolved in water and the solution was acidified with concentrated hydrochloric acid. The dark brown solid was collected, washed with water and dried. The crude solid was dissolved in ethyl acetate, the solution was treated with charcoal, filtered, and the solvent was evaporated to give 4-chloro-2-carboxyphenylacetonitrile (1.70 g) as pale yellow crystals mp 120° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04409017 |
|---|
| 出典データセット | uspto-grants-1983_10 |
|---|
| ORD ID | ord-c2956ed37b054290b05212aa42a30c0c |
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| 出典メモ | uspto-grants-1983_10 |
|---|
