Acetamide → 1-[2-(Dimethylamino)-1-(3-trifluoromethylphenoxy)ethyl]cyclohexanol
反応式
C(N)(=O)C.FC(F)(F)[C:7]1[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=1)[O:10]CC(O)=O.[CH3:20][N:21]([CH3:36])[C:22](=O)[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=1.B.O1CCCC1>>[CH3:20][N:21]([CH3:36])[CH2:22][CH:23]([C:9]1([OH:10])[CH2:15][CH2:16][CH2:17][CH2:7][CH2:8]1)[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=1参加物
5
実験手順
N,N-dimethyl-2-[3-trifluoromethyl)phenoxy]acetamide, prepared from 2-[3-trifluoromethylphenoxyl]acetic acid in accordance with Example 1 was converted to the amide which was reduced with Borane/tetrahydrofuran as in Example 3. The title compound was obtained and its hydrochloride salt prepared, m.p. 210°-211° C.