Aminoacetamidine Dihydrobromide → 2-Amino-7-cyclohexyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

反応式

[CH:1]1([N:7]2[CH2:13][CH2:12][C:11](O[Si](C)(C)C)=[C:10](O[Si](C)(C)C)[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br.Br.[NH2:26][CH2:27][C:28]([NH2:30])=[NH:29]>>[NH2:30][C:28]1[CH:27]=[N:26][C:11]2[CH2:12][CH2:13][N:7]([CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH2:8][CH2:9][C:10]=2[N:29]=1

参加物

反応物 2

HCID 16211382Aminoacetamidine Dihydrobromide

HCID 204364681-Cyclohexyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)azepine

生成物 1

HCID 130370402-Amino-7-cyclohexyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

実験手順

This compound was prepared analogous to Example 1 from 1-cyclohexyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)azepine and 2-amino-acetamidine dihydrobromide.

出典と根拠

ORDレコード: ord-a343882df9c74208a68011554b061e57
出典データセット: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04409220

反応ノート

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