Dimethylamine → HCID 12074949、化合物

HRID 647501ノート

反応式

HRID 647501 の反応式
[CH2:1]([O:8][C:9]1[C:10]([CH2:15][N:16]2C(=O)C3=CC=CC=C3C2=O)=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CNC>O>[NH2:16][CH2:15][C:10]1[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=[CH:12][N:11]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 132175412-{[3-(Benzyloxy)pyridin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 12074949HCID 12074949、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Heat 75 gm of 3-benzyloxy-2-phthalimidomethylpyridine under reflux for one hour in 550 ml of a 40% aqueous dimethylamine solution. Cool the resulting reaction mixture to room temperature, then dilute it with 550 ml water and extract with dichloromethane. Wash the dichloromethane extract with brine and dry over anhydrous sodium sulfate. Filter the dried reaction mixture and remove the solvent dichloromethane from the filtrate under reduced pressure, yielding 2-aminomethyl-3-phenylmethoxypyridine, BP 145°-155°/0.5 mm.

後処理

  1. temperatureCool
  2. customthe resulting reaction mixture to room temperature
  3. extractionextract with dichloromethane
  4. washWash the dichloromethane
  5. extractionextract with brine
  6. dry with materialdry over anhydrous sodium sulfate
  7. filtrationFilter
  8. customthe dried reaction mixture
  9. customremove the solvent dichloromethane from the filtrate under reduced pressure

出典と根拠

ORDレコード
ord-6fa904c302dd48f986b7419cefb74d14
出典データセット
uspto-grants-1983_10
特許番号
US04409226

反応ノート

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