HCID 12926609、化合物 → SR 57227A

HRID 647516ノート

反応式

HRID 647516 の反応式
C([NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[N:12]=2)[CH2:7][CH2:6]1)(=O)C>Cl>[NH2:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[N:12]=2)[CH2:7][CH2:6]1

参加物

3

反応物 1

HCID 12926609HCID 12926609、化合物

生成物 1

HCID 131747SR 57227A収率 72%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 0.482 mole of 4-acetamido-1-(6-chloro-2-pyridyl)piperidine in 610 ml of 6 N hydrochloric acid is heated at reflux for 8 hours, then the reaction mixture is cooled and concentrated under reduced pressure. The residue is treated with 4 N sodium hydroxide up to a clearly basic pH and the oil which separates is extracted with diethyl ether. The organic phase is washed with water, dried over anhydrous sodium sulfate and evaporated to dryness. The oily residue is crystallised by diisopropylic ether. 4-amino-1-(6-chloro-2-pyridyl)piperidine is thus obtained; m.p. 36° to 38° C.

後処理

  1. temperatureat reflux for 8 hours
  2. temperaturethe reaction mixture is cooled
  3. concentrationconcentrated under reduced pressure
  4. additionThe residue is treated with 4 N sodium hydroxide up to a clearly basic pH
  5. extractionthe oil which separates is extracted with diethyl ether
  6. washThe organic phase is washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated to dryness
  9. customThe oily residue is crystallised by diisopropylic ether

出典と根拠

ORDレコード
ord-c6372d8c214444b3acdbfac197ae593c
出典データセット
uspto-grants-1983_10
特許番号
US04409228

反応ノート

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