Ammonia → 3-[N-{2-nitro-5-(2-chloro-4-methylsulphonylphenoxy)phenyl}amino]propionamide

HRID 64758ノート

反応式

HRID 64758 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[NH:22][CH2:23][CH2:24][C:25]([O:27]C)=O)([O-:3])=[O:2].[NH3:29]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[NH:22][CH2:23][CH2:24][C:25]([NH2:29])=[O:27])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 222AmmoniaHCID 20237335methyl 3-[N-{2-nitro-5-(2-chloro-4-methylsulphonylphenoxy)phenyl}amino]propionate

生成物 1

HCID 202373603-[N-{2-nitro-5-(2-chloro-4-methylsulphonylphenoxy)phenyl}amino]propionamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The ester (7), obtained according to Example III, in an amount of 1.6 g was suspended in 40 ml of methanol. Ammonia was introduced until saturation and then the reaction mixture was stirred for two days. The solid material was sucked off and recrystallized from ethylacetate. The desired product was obtained in a yield of 0.9 g; melting point 196° C.

後処理

  1. customrecrystallized from ethylacetate

出典と根拠

ORDレコード
ord-cf111e7778574e5380b809ac092446f2
出典データセット
uspto-grants-1986_09
特許番号
US04609753

反応ノート

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