Pyridine → methyl 2-(dimethylamino)-N-[[[[[(diethoxyphosphinothioyl)methylamino]sulfinyl]methylamino]carbonyl]oxy]-2-oxoethanimidothioate

関与物質

反応手順

To a solution of methyl 2-(dimethylamino)-N-[[(methylamino)carbonyl]oxy]-2-oxoethanimidothioate (3.29 g, 0.015 mole) in dry pyridine 15 ml was added at one time thionyl chloride (1.79 g, 0.015 mole) at -30°. The mixture was allowed to come to room temperature and then stirred for 15 minutes. The mixture was cooled to 0° and O,O-diethyl methylphosphoramidothioate (2.75 g, 0.01 mole) was added. The mixture was allowed to come to room temperature for 1 hour, poured into ice water and extracted with benzene. The benzene solution was washed with water 4 times and then dried over anhydrous sodium sulfate. The benzene was removed under reduced pressure to give a crude product of the formula below. ##STR40##

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