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Dl-Phenylalanine → D-phenylalanine N-carbobenzoxy-D-aspartic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dl-Phenylalanine | HCID 994 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | (2R)-2-(((benzyloxy)carbonyl)amino)butanedioic acid | HCID 5289152 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | D-phenylalanine N-carbobenzoxy-D-aspartic acid | HCID 13714281 | 32.1% |
反応手順
Eight grams of DL-phenylalanine and 1.2 g of sulfuric acid was suspended in 100 ml of water at 40° C. Ten grams of N-carbobenzoxy-D-aspartic acid was added to the solution over five hours, while this solution was continuously stirred. The resulting crystal was separated, washed with 10 ml of water and dried to give 5.2 g of a D-phenylalanine N-carbobenzoxy-D-aspartic acid. Analysis revealed that the optical purity of the D-phenylalnine was 98%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04610827 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-987bea95ecff469face1ae081f9f5f8e |
| 出典メモ | uspto-grants-1986_09 |