Acetic Anhydride → HCID 54045935、化合物

HRID 647861ノート

反応式

HRID 647861 の反応式
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:15][CH:14]([OH:16])[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[N:11]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:10]1=[O:27])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[C:28]([O:16][CH:14]1[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[N:11]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:10](=[O:27])[C@@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:15]1)(=[O:30])[CH3:29]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 13604465HCID 13604465、化合物

生成物 1

HCID 54045935HCID 54045935、化合物

実験手順

A solution of 3-(S)-t-butyloxycarbonylamino-1-ethoxycarbonylmethyl-5-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one (previously described, 1.0 g) in acetic anhydride (20 ml) was maintained at 80° for 3 hours. The reaction mixture was cooled to room temperature and the solvents removed under reduced pressure. Ether (100 ml) was added, and the resulting solution washed with water (50 ml) and dried over magnesium sulfate. The solvent was removed under reduced pressure to give 5-acetoxy-3-(S)-t-butyloxycarbonylamino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one as a pale yellow oil which was used without further purification.

後処理

  1. customthe solvents removed under reduced pressure
  2. additionEther (100 ml) was added
  3. washthe resulting solution washed with water (50 ml)
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-b9daec6cc49743a4a62955705c1f8530
出典データセット
uspto-grants-1983_10
特許番号
US04410520

反応ノート

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