関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | DL-leucine | HCID 857 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | N-(Benzyloxycarbonyl)aspartic acid | HCID 2723942 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | L-leucine N-carbobenzoxy-L-aspartic acid | HCID 70458343 | 50% |
反応手順
Ten grams of DL-leucine, 12.2 g of N-carbobenzoxy-L-aspartic acid and 1.9 g of sulfuric acid were added to 500 ml of water and the resulting solution was heated to 60° C. This solution was cooled to 10° C. at a rate of 2° C. per hour while stirring, and was stirred for another two hours. The resulting crystal was separated, washed with 30 ml of water and dried to give 9.1 g of an L-leucine/N-carbobenzoxy-L-aspartic acid. Analysis showed that the optical purity of the L-leucine was 95%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04610827 |
|---|
| 出典データセット | uspto-grants-1986_09 |
|---|
| ORD ID | ord-80bd70f61956487b962e5c35298033de |
|---|
| 出典メモ | uspto-grants-1986_09 |
|---|
