1-Sec-butyl-piperidin-4-one → 9-Sec.-butyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

HRID 647936ノート

反応式

HRID 647936 の反応式
Cl.[NH:2]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][CH:10]=[C:9]([CH3:12])[C:8]=2[CH:13]=1)N.[CH:14]([N:18]1[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1)([CH2:16][CH3:17])[CH3:15].C(O)(C)C.Cl>C(O)(C)C>[CH:14]([N:18]1[CH2:23][CH2:22][C:21]2[NH:2][C:4]3[C:13]([C:20]=2[CH2:19]1)=[C:8]1[C:9]([CH3:12])=[CH:10][S:11][C:7]1=[CH:6][CH:5]=3)([CH2:16][CH3:17])[CH3:15]

参加物

5

反応物 3

HCID 131828071-Sec-butyl-piperidin-4-oneHCID 204843225-Hydrazino-3-methylbenzothiophene hydrochlorideHCID 21912024Isopropanol hydrochloride

生成物 1

HCID 204842929-Sec.-butyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

11 g of 5-hydrazino-3-methylbenzothiophene hydrochloride and 8.5 g of 1-sec.-butyl-4-piperidone are boiled in 35 ml of isopropanol, and during this procedure isopropanol/HCl are added dropwise. The mixture is then evaporated, the residue is taken up in water and the mixture is rendered alkaline and extracted with methylene chloride. After washing and drying the organic phase, it is evaporated and the residue is recrystallised from cyclohexane. Melting point: 136°-137° C.

後処理

  1. customThe mixture is then evaporated
  2. extractionextracted with methylene chloride
  3. washAfter washing
  4. customdrying the organic phase, it
  5. customis evaporated
  6. customthe residue is recrystallised from cyclohexane

出典と根拠

ORDレコード
ord-df7cf8c6b553416f8d8f5dedd3a353ab
出典データセット
uspto-grants-1983_10
特許番号
US04410536

反応ノート

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