Morpholine → 4-(3-Chloropyrazin-2-YL)morpholine

HRID 647958

反応式

HRID 647958 の反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:7]1[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:3][CH:4]=[CH:5][N:6]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 785752,3-Dichloropyrazine

生成物 1

HCID 205289944-(3-Chloropyrazin-2-YL)morpholine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

149 g of 2,3-dichloropyrazine, 300 g of morpholine and 400 ml of water are stirred for 16 hours at 40° C. The reaction mixture is then extracted by shaking with ether. The ether extracts are washed with water until neutral, dried over sodium sulphate and evaporated in a waterpump vacuum. The residue is distilled in a waterpump vacuum. 2-Chloro-3-morpholinyl-pyrazine, boiling point 162°-165° C./15 mm Hg, is thus obtained.

後処理

  1. extractionThe reaction mixture is then extracted
  2. washThe ether extracts are washed with water until neutral,
  3. dry with materialdried over sodium sulphate
  4. customevaporated in a waterpump vacuum
  5. distillationThe residue is distilled in a waterpump vacuum

出典と根拠

ORDレコード
ord-b14340795be043bf941bccc90549a404
出典データセット
uspto-grants-1983_10
特許番号
US04410530

関連ノート

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