Ethanol → N-[2-{1 [(2-chlorophenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}ethyl]phenylalanine

HRID 6480

反応式

HRID 6480 の反応式
C[O:2][C:3](=[O:32])[C@H:4]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][CH2:6][CH2:7][C:8]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[C:11]([CH2:21][CH2:22][CH2:23][CH3:24])=[N:10][CH:9]=1.[OH-].[K+].O.C(O)C>CCOCC>[Cl:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][N:12]1[C:8]([CH2:7][CH2:6][NH:5][C@H:4]([C:3]([OH:32])=[O:2])[CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:9][N:10]=[C:11]1[CH2:21][CH2:22][CH2:23][CH3:24]

参加物

6

反応物 4

HCID 702EthanolHCID 962WaterHCID 14797Potassium HydroxideHCID 22847671N-[2-{1-[(2 chlorophenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}ethyl]phenylalanine methyl ester2 回

生成物 1

HCID 54198642N-[2-{1 [(2-chlorophenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}ethyl]phenylalanine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The procedure of Example 2 (ii) was followed using 0.9 g (1.99 mmol) of N-[2-{1-[(2-chlorophenyl)methyl]-2-n-butyl-1H-imidazol -5-yl}ethyl]phenylalanine methyl ester, 0.33 g of potassium hydroxide, 15 ml of water and 25 ml of ethanol to afford after workup 0.54 q of product. Trituration with ether provided the title compound; mp 78°-80° C. (free base) and mp 232°-233° C. (for the dihydrochloride salt).

後処理

  1. customto afford after workup 0.54 q of product

出典と根拠

ORDレコード
ord-0938af2f3f7e40ac8becd6f17afdc7e9
出典データセット
uspto-grants-1993_09
特許番号
US05248689

関連ノート

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