Methanol → methyl 6-methyl-1H-indole-2-carboxylate
反応式
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([OH:13])=[O:12])[NH:8]2)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.[CH3:19]O>>[CH3:19][O:12][C:11]([C:7]1[NH:8][C:9]2[C:5]([CH:6]=1)=[CH:4][CH:3]=[C:2]([CH3:1])[CH:10]=2)=[O:13]参加物
4
実験手順
A solution of 6-methylindole-2-carboxylic acid (38.2 g.) in methanol (400 ml.) containing phosphorus oxychloride (5 ml.) was heated under reflux for 4 hours and then evaporated. The residue was dissolved in chloroform and the solution was washed successively with water and sodium bicarbonate solution and then dried (Na2SO4). Evaporation of the solvent gave a solid which was crystallized from methanol to give 6-methylindole-2-carboxylic acid methyl ester (28.1 g.), m.p. 128°-131° C.
後処理
- temperaturewas heated
- temperatureunder reflux for 4 hours
- customevaporated
- dissolutionThe residue was dissolved in chloroform
- washthe solution was washed successively with water and sodium bicarbonate solution
- dry with materialdried (Na2SO4)
- customEvaporation of the solvent
- customgave a solid which
- customwas crystallized from methanol
出典と根拠
- ORDレコード
- ord-6ac1321ca2ad4af2af5ee61526032892
- 出典データセット
- uspto-grants-1983_10
- 特許番号
- US04410539
反応ノート
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