化工社化工社 化学情報印刷レポート · 研究参考用
Hexamethyldisilazane → Ethyl 2-sulfamoylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexamethyldisilazane | HCID 13838 | — |
| 反応物 | Ethyl (chlorosulfonyl)acetate | HCID 12225100 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 2-sulfamoylacetate | HCID 12225113 | — |
反応手順
A solution of 54.6 g (0.29 mole) ethoxy carbonyl methanesulfonyl chloride in 250 ml methylene chloride is stirred at 0° under a nitrogen atmosphere while 46.8 g (0.29 mole) hexamethyldisilazane is added dropwise. The resulting cloudy solution is allowed to warm to 25° over one hour and then evaporated in vacuo to an oil which crystallizes: yield of the title product is 48.4 g (100%), mp 63°-67°; lit.1 mp 67°-68°, lit2 mp 66°-68°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04411899 |
| 出典データセット | uspto-grants-1983_10 |
| ORD ID | ord-ccbb9e39cb8f49eaa411d4555b4ce37c |
| 出典メモ | uspto-grants-1983_10 |