Hexamethyldisilazane → 4-Amino-3-ethoxy-5-ethoxycarbonylisothiazole-1,1-dioxide

HRID 648190ノート

反応式

HRID 648190 の反応式
[CH2:1]([O:3][C:4]1[C:8](OCC)=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[S:6](=[O:18])(=[O:17])[N:5]=1)[CH3:2].C[Si](C)(C)[NH:21][Si](C)(C)C>C(Cl)Cl>[CH2:1]([O:3][C:4]1[C:8]([NH2:21])=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[S:6](=[O:18])(=[O:17])[N:5]=1)[CH3:2]

参加物

4

反応物 2

HCID 13838HexamethyldisilazaneHCID 128421823,4-Diethoxy-5-ethoxycarbonyl isothiazole-1,1-dioxide

生成物 1

HCID 128421834-Amino-3-ethoxy-5-ethoxycarbonylisothiazole-1,1-dioxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Under a nitrogen atmosphere a solution of 1.41 g (5.3 mmol) of the Example 3 compound in 15 ml of methylene chloride is stirred in an ice bath while a solution of 1.2 g (7.9 mmol) hexamethyldisilazane in 10 ml methylene chloride is added dropwise. The solution is allowed to warm to room temperature at which temperature stirring is continued for 18 hours. The solution is then evaporated in vacuo to an oil which is redissolved in 20 ml of a mixture of methylene chloride (15)-ethanol (5). After stirring at room temperature for one hour, the solution is again concentrated in vacuo, leaving a solid, 1.1 g (85%), mp 163°-165°. Recrystallization from ethyl acetate provides analytically pure title compound, mp 172.5°-173°.

後処理

  1. additionis added dropwise
  2. customThe solution is then evaporated in vacuo to an oil which
  3. dissolutionis redissolved in 20 ml of a mixture of methylene chloride (15)-ethanol (5)
  4. stirringAfter stirring at room temperature for one hour
  5. concentrationthe solution is again concentrated in vacuo
  6. customleaving a solid, 1.1 g (85%), mp 163°-165°
  7. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-8c8dc2b2912e463c905d438b5768ca67
出典データセット
uspto-grants-1983_10
特許番号
US04411899

反応ノート

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