Phenol → N-(2-fluoro-4-trifluoromethylphenyl)valin
反応式
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH:16]([CH:17]([CH3:19])[CH3:18])[C:15](=[O:20])[O:14]C1=O.C1(O)C=CC=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][C@H:16]([C:15]([OH:20])=[O:14])[CH:17]([CH3:19])[CH3:18]参加物
3
実験手順
3-(2-Fluoro-4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione is reacted with phenol using the procedure of Example 75 to give the phenyl ester of N-(2-fluoro-4-trifluoromethylphenyl)valine, which is reacted with NaHS using the method of Hirakayaski et al., Bull. Chem. Soc. Japan 38, 320 (1965) to give the sodium salt of the thioacid. ##STR27##
出典と根拠
- ORDレコード
- ord-ba7cfefb609c4ee7ae1a19a453089c46
- 出典データセット
- uspto-grants-1983_10
- 特許番号
- US04411912
反応ノート
読み込み中…