(S)-Benzyl 2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate → (2S)-N,N-dimethylpyrrolidine-2-carboxamide

HRID 64835ノート

反応式

HRID 64835 の反応式
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]([N:18]([CH3:20])[CH3:19])=[O:17])=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[CH3:19][N:18]([CH3:20])[C:16]([C@@H:12]1[CH2:13][CH2:14][CH2:15][NH:11]1)=[O:17]

参加物

5

反応物 2

HCID 13564352(S)-Benzyl 2-(dimethylcarbamoyl)pyrrolidine-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 7408249(2S)-N,N-dimethylpyrrolidine-2-carboxamide収率 99%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

In 86 ml of ethanol was dissolved 4.3 g of compound (88) and after adding thereto 210 mg of 10% palladium-carbon, the mixture was stirred vigorously for 90 minutes in a hydrogen stream. After filtering off the catalyst, ethanol was distilled off under reduced pressure to provide 2.19 g of crude (S)-N,N-dimethyl-2-pyrrolidinecarboxamide (89).

後処理

  1. additionafter adding
  2. filtrationAfter filtering off the catalyst, ethanol
  3. distillationwas distilled off under reduced pressure

出典と根拠

ORDレコード
ord-d3c51ff67eed45f3abde59bb3b613e97
出典データセット
uspto-grants-1986_09
特許番号
US04610821

反応ノート

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