Methane → 6-Ethyl-5-propanoylpyridin-2(1H)-one

HRID 648380ノート

反応式

HRID 648380 の反応式
[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[C:6](=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])C(O)=O)[CH3:2].C>C(O)C>[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[CH:6]=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])[CH3:2]

参加物

4

反応物 2

HCID 297MethaneHCID 132365116-Ethyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carboxylic acid

生成物 1

HCID 132365086-Ethyl-5-propanoylpyridin-2(1H)-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 15 g portion of 6-ethyl-1,2-dihydro-2-oxo-5-(n-propanoyl)-nicotinic acid was heated in an oil bath at 235°-240° C. for 5 hours, cooled and the reaction mixture dissolved in hot ethanol, treated with decolorizing charcoal and filtered. The filtrate was evaporated in dryness and the residue recrystallized from isopropyl alcohol to yield 8.2 g of 6-ethyl-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 138°-140° C.

後処理

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe filtrate was evaporated in dryness
  4. customthe residue recrystallized from isopropyl alcohol

出典と根拠

ORDレコード
ord-54804d8e4dd445e885a2f4a043888047
出典データセット
uspto-grants-1983_10
特許番号
US04412077

反応ノート

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