Methyl acetoacetate → HCID 14098292、化合物

HRID 648455ノート

反応式

HRID 648455 の反応式
[CH:1]([C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[N:11][C:6]2=[N:5][CH:4]=1)=O.[NH2:12]/[C:13](/[CH3:19])=[CH:14]\[C:15]([O:17][CH3:18])=[O:16].[C:20]([O:26][CH3:27])(=[O:25])[CH2:21][C:22]([CH3:24])=O>C(O)(C)C.CCOCC>[CH3:19][C:13]1[NH:12][C:22]([CH3:24])=[C:21]([C:20]([O:26][CH3:27])=[O:25])[CH:1]([C:3]2[N:7]3[CH:8]=[CH:9][CH:10]=[N:11][C:6]3=[N:5][CH:4]=2)[C:14]=1[C:15]([O:17][CH3:18])=[O:16]

参加物

6

反応物 3

HCID 7757Methyl acetoacetateHCID 404535Imidazo[1,2-a]pyrimidine-3-carboxaldehydeHCID 643918Methyl 3-aminocrotonate

生成物 1

HCID 14098292HCID 14098292、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 3776Isopropanol溶媒

実験手順

To 0.5 g (3.4 mmol) (2) in 10 ml isopropanol was added 0.39 g (3.4 mmol) methyl 3-aminocrotonate and 0.39 g (3.4 mmol) methyl acetoacetate and the resulting solution refluxed overnight. The cooled reaction mixture was then diluted with 15 ml ether and stirred for 1 hour. The tan solid was filtered off and recrystallized from ethyl acetate to give pure (3), m.p. 202°-205° (dec).

後処理

  1. temperaturethe resulting solution refluxed overnight
  2. customThe cooled reaction mixture
  3. filtrationThe tan solid was filtered off
  4. customrecrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-24719ea08c054aa69393062f22cb3349
出典データセット
uspto-grants-1988_04
特許番号
US04735956

反応ノート

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