Isopropanol → HCID 14098295、化合物

HRID 648457ノート

反応式

HRID 648457 の反応式
O1[C:5](=O)[CH:4]=[NH+:3][N-]1.[CH:7]([C:9]1[C:13](=O)O[N-][N+:10]=1[CH3:15])=O.[NH2:16]/[C:17](/[CH3:23])=[CH:18]\[C:19]([O:21][CH3:22])=[O:20].[C:24]([O:30][CH3:31])(=[O:29])[CH2:25][C:26]([CH3:28])=O.[CH:32](O)(C)[CH3:33]>>[CH3:23][C:17]1[NH:16][C:26]([CH3:28])=[C:25]([C:24]([O:30][CH3:31])=[O:29])[CH:7]([C:9]2[N:10]=[CH:15][N:3]3[CH:4]=[CH:5][CH:33]=[CH:32][C:13]=23)[C:18]=1[C:19]([O:21][CH3:22])=[O:20]

参加物

5

反応物 4

HCID 3776IsopropanolHCID 7757Methyl acetoacetateHCID 643918Methyl 3-aminocrotonateHCID 178482033HCID 178482033、化合物

生成物 1

HCID 14098295HCID 14098295、化合物

実験手順

To 1.02 g (7 mmol) 1-formylimidazo[1,5-a]pyridine (1) in 20 ml isopropanol was added 0.81 g methyl 3-aminocrotonate and 0.81 g (7 mmol) methyl acetoacetate and the resulting solution refluxed for 14 hours. The cooled reaction mixture was filtered to give a yellow solid which was recrystallized from CH3OH to afford pure (2), m.p. 265°-267° (dec).

後処理

  1. temperaturethe resulting solution refluxed for 14 hours
  2. customThe cooled reaction mixture
  3. filtrationwas filtered
  4. customto give a yellow solid which
  5. customwas recrystallized from CH3OH

出典と根拠

ORDレコード
ord-36f323b970854b62bf0b746e96bb7e51
出典データセット
uspto-grants-1988_04
特許番号
US04735956

反応ノート

読み込み中…