Methanol → Methyl 4-(methylsulfonyl)benzoate

HRID 64846

反応式

HRID 64846 の反応式
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].S(=O)(=O)(O)O.[CH3:19]O>>[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:11][CH3:19])=[O:10])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 77670p-(Methylsulphonyl)benzoic acid

生成物 1

HCID 6432253Methyl 4-(methylsulfonyl)benzoate

実験手順

250 ml of a desiccated methanol solution containing 50 g (0.25 mol) of p-methylsulfonylbenzoic acid and 10 ml of concentrated sulfuric acid was refluxed by heating for 8 hours. The reaction mixture was then cooled with ice and the crystals thus precipitated were collected by filtration and washed with methanol to obtain 48.2 g (0.225 mol) of the above described compound.

後処理

  1. temperaturewas refluxed
  2. temperatureby heating for 8 hours
  3. temperatureThe reaction mixture was then cooled with ice
  4. customthe crystals thus precipitated
  5. filtrationwere collected by filtration
  6. washwashed with methanol
  7. customto obtain 48.2 g (0.225 mol) of the

出典と根拠

ORDレコード
ord-f4eb3cf917914522b04af21b67219266
出典データセット
uspto-grants-1986_09
特許番号
US04610957

関連ノート

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