Hydrochloric Acid → 4-[(Piperidin-4-yl)sulfanyl]pyridine--hydrogen chloride (1/2)

HRID 648504ノート

反応式

HRID 648504 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH:8]2[CH2:13][CH2:12][N:11](C(OC3C=CC=CC=3)=O)[CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[ClH:23]>>[ClH:23].[ClH:23].[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 13825040HCID 13825040、化合物

生成物 1

HCID 219060714-[(Piperidin-4-yl)sulfanyl]pyridine--hydrogen chloride (1/2)

実験手順

A solution of phenyl 4-[(4-pyridyl)thio]-1-piperidine-carboxylate (5.0 g) in conc. hydrochloric acid (50 ml) was refluxed for 7 hours and concentrated to dryness in vacuo. The crystalline residue was washed with isopropanol and recrystallized from methanol to give 4-[(4-pyridyl)thio]piperidine dihydrochloride (2.85 g).

後処理

  1. concentrationconcentrated to dryness in vacuo
  2. washThe crystalline residue was washed with isopropanol
  3. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-6057c1253b1a4551b178773547774813
出典データセット
uspto-grants-1988_04
特許番号
US04735952

反応ノート

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