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4-Aminobenzoic Acid → 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | Ethyl 4-chloro-7-(trifluoromethyl)quinoline-3-carboxylate | HCID 14515676 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride | HCID 13825035 | 61.1% |
反応手順
A mixture of ethyl 4-chloro-7-(trifluoromethyl)-3-quinoline-carboxylate (3.04 g) and 4-aminobenzoic acid (1.37 g) in tetrahydrofuran (53 ml) was stirred under reflux for 10 hours and cooled to room temperature. The precipitates were collected and washed with tetrahydrofuran to give 4-[[3-ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride (2.69 g) as yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04735952 |
| 出典データセット | uspto-grants-1988_04 |
| ORD ID | ord-bebe478147bd4c42b33c1475c46188a7 |
| 出典メモ | uspto-grants-1988_04 |