Benzenesulfonyl chloride → N-[4-(1H-Imidazol-1-yl)butyl]benzenesulfonamide

HRID 64852ノート

反応式

HRID 64852 の反応式
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:11]1([CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH:15]=[CH:14][N:13]=[CH:12]1.C(=O)(O)[O-].[Na+]>ClCCl>[N:11]1([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

5

反応物 3

HCID 7369Benzenesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 43794804-(1H-imidazol-1-yl)butan-1-amine

生成物 1

HCID 13687303N-[4-(1H-Imidazol-1-yl)butyl]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Following the general procedure of Example 8 and reacting the appropriate benzenesulfonyl chloride with 1H-imdazol-1-propanamine or 1H-imidazol-1-butanamine in the presence of saturated sodium bicarbonate in dichloromethane for 16-48 hours, then crystallizing the respective products with ether and, if necessary, recrystallization from ethyl acetate or ethanol/dichloromethane gave the compounds of Examples 9-12 found in Table III below and gives the compounds of Examples 13-15 in Table III.

後処理

  1. customfor 16-48 hours
  2. customcrystallizing the respective products with ether
  3. customif necessary, recrystallization from ethyl acetate or ethanol/dichloromethane

出典と根拠

ORDレコード
ord-7004de13ede5493f81982239cbef4afc
出典データセット
uspto-grants-1986_09
特許番号
US04610981

反応ノート

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