Hydrochloric Acid → 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylic acid

HRID 648543ノート

反応式

HRID 648543 の反応式
[O:1]=[C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][C:9]([C:18]([O:20]C)=[O:19])=[C:8]2[N:3]1[CH:4]=[CH:5][C:6]1[CH:24]=[CH:23][S:22][C:7]=12.[OH-].[K+].Cl>O.CO>[O:1]=[C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][C:9]([C:18]([OH:20])=[O:19])=[C:8]2[N:3]1[CH:4]=[CH:5][C:6]1[CH:24]=[CH:23][S:22][C:7]=12

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 14666705methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate

生成物 1

HCID 146667437-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylic acid

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

(aa) 1.34 g of methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate were heated under reflux and under argon with 0.45 g of potassium hydroxide in 25 ml of water/methanol. After the reaction was completed, the mixture was acidified with 2N hydrochloric acid and the yellow crystals were removed by filtration. After washing with water, the acid was dried in vacuo for several hours. There was obtained 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylic acid of m.p. 185°-186° (dec.).

後処理

  1. customthe yellow crystals were removed by filtration
  2. washAfter washing with water
  3. customthe acid was dried in vacuo for several hours

出典と根拠

ORDレコード
ord-5c4713c9b873460cb48a915d19cd1ffe
出典データセット
uspto-grants-1988_04
特許番号
US04735940

反応ノート

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