Methyl Acrylate → Methyl 3-(phenylthio)propionate

HRID 648624ノート

反応式

HRID 648624 の反応式
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[C:15]([O:19][CH3:20])(=[O:18])[CH:16]=[CH2:17]>C(Cl)Cl>[C:1]1([S:7][CH2:17][CH2:16][C:15]([O:19][CH3:20])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 7294Methyl AcrylateHCID 7969ThiophenolHCID 8471Triethylamine

生成物 1

HCID 350367Methyl 3-(phenylthio)propionate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thiophenol (440 mg, 4 mmol) and Et3N (70 μl, 0.5 mmol) were dissolved in CH2Cl2 (5 ml). Methyl acrylate (412 mg, 4.8 mmol) was added dropwise. The reaction was exothermic. After stirring at room temperature for 30 minutes, the excess methyl acrylate was removed in vacuo. TLC: silica gel, Et2O-hexane 1:2, UV Rf =0.58. The crude title ester was used without further purification.

後処理

  1. customthe excess methyl acrylate was removed in vacuo
  2. customThe crude title ester was used without further purification

出典と根拠

ORDレコード
ord-49eb8f9cfeef495d87447e5574807b06
出典データセット
uspto-grants-1988_04
特許番号
US04735962

反応ノート

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