化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-(bromomethyl)benzoate → N-[{1-[(4-Carboxyphenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}methyl]-beta-(2-thienyl)alanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 反応物 | L-Phenylalanine, methyl ester | HCID 736234 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | (S)-Methyl 2-amino-3-(thiophen-2-yl)propanoate | HCID 10899351 | — |
| 反応物 | 2-n-butyl 4-chloro 1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole | HCID 13074095 | — |
| 反応物 | N-[{1-[(2 chlorophenyl)methyl]-2-n-butyl-4-chloro-1H-imidazol-5-yl}methyl]phenylalanine | HCID 53988647 | — |
| 生成物 | N-[{1-[(4-Carboxyphenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}methyl]-beta-(2-thienyl)alanine | HCID 44316969 | — |
反応手順
The title compound was prepared following the procedure of Example 3 [(i) method B and (ii)] replacing 2-chlorobenzyl bromide with 4-carbomethoxybenzyl bromide, phenylalanine methyl ester with β-(2-thienyl)alanine methyl ester and sodium cyanoborohydride with sodium borohydride; mp 151°-152° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248689 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-7b615b850a714ed28667ec5cac687e9c |
| 出典メモ | uspto-grants-1993_09 |