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Dichloromethane → 4-(4-Chlorobenzoyl)-piperazin-1-yl-acetic acid morpholide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 2-Chlorobenzoyl chloride | HCID 69110 | — |
| 反応物 | 1-(Morpholinocarbonylmethyl)piperazine | HCID 100622 | — |
| 生成物 | 4-(4-Chlorobenzoyl)-piperazin-1-yl-acetic acid morpholide hydrochloride | HCID 86740986 | — |
反応手順
5 g of piperazinoacetic acid morpholide and 4.2 g of chlorobenzoyl chloride are brought together in 50 ml of methylene chloride at 0° C. The mixture is stirred at room temperature for 2 hours and cooled again to 0° C., whereupon a precipitate separates out, and is recrystallised from isopropanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04610984 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-00c9c449b98d467ca6ce6714565bfd2c |
| 出典メモ | uspto-grants-1986_09 |