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Phosphorus oxychloride → 2-Chloro-4-(4-fluorobenzoyl)-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 4-(4-fluorobenzoyl)-pyridine N-oxide | HCID 54143203 | — |
| 生成物 | 2-Chloro-4-(4-fluorobenzoyl)-pyridine | HCID 20145710 | — |
反応手順
0.88 g 4-(4-fluorobenzoyl)-pyridine N-oxide and 50 ml POCl3 are refluxed for 2 hrs. Excess POCl3 is distilled at normal pressure. The crude is treated with slightly alkaline cold water and then extracted with methylene chloride. Working as usual affords 0.80 g of title product, identical with that obtained by the Friedel-Crafts process (see Ex. 3d).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04736037 |
| 出典データセット | uspto-grants-1988_04 |
| ORD ID | ord-297ae98322534e3db5a0a6253499a89f |
| 出典メモ | uspto-grants-1988_04 |