Phosphorus oxychloride → (6-Chloro-2-pyridinyl)phenylmethanone
反応式
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:18]>>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:18])[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
1.5 g 2-benzoyl-pyridine N-oxide (T. Kato et. al., see reference in Ex. 11) and 3.6 ml POCl3 are refluxed for 25 minutes. The cooled mixture is added to slightly alkaline ice:water, extracted with chloroform, the organic extract dried and solvent removed in vacuo. Yield: 1.1 g of title product, which by thin layer and gas chromatography is identical with that described in Ex. 7.
後処理
- additionThe cooled mixture is added to slightly alkaline ice
- extractionwater, extracted with chloroform
- extractionthe organic extract
- customdried
- customsolvent removed in vacuo
出典と根拠
- ORDレコード
- ord-be00d624542341b28593406c166b47c8
- 出典データセット
- uspto-grants-1988_04
- 特許番号
- US04736037
反応ノート
読み込み中…