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3-Benzoyl-2-chloropyridine → 3-Pyridinemethanol, 2-chloro-alpha-phenyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Benzoyl-2-chloropyridine | HCID 824619 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-Pyridinemethanol, 2-chloro-alpha-phenyl- | HCID 3061980 | 42.1% |
反応手順
2.4 g lithium aluminium hydride is added very slowly to 10.6 g 3-benzoyl-2-chloropyridine in 100 ml anhydrous pyridine. After stirring for 2 hrs. at room temperature, the solvent is distilled in vacuo, the residue is added to 5% aqueous HCl and extracted with ether. Working as usual there is obtained 4.5 g of a product, identical with that obtained as in (a).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04736037 |
| 出典データセット | uspto-grants-1988_04 |
| ORD ID | ord-c6f08f3ded5446bc9b17e35e96c8fe3d |
| 出典メモ | uspto-grants-1988_04 |