2-(Piperidine-1-carbonyl)aniline → 1-[2-(2-Methyl-4-pyridinylamino)benzoyl]piperidine

HRID 64890

反応式

HRID 64890 の反応式
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5].[CH3:16][C:17]1[CH:22]=[C:21](Cl)[CH:20]=[CH:19][N:18]=1>C(O)(=O)C>[CH3:16][C:17]1[CH:22]=[C:21]([NH:1][C:2]2[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=2[C:4]([N:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)=[O:5])[CH:20]=[CH:19][N:18]=1

参加物

4

反応物 2

HCID 5587302-(Piperidine-1-carbonyl)anilineHCID 5813924-Chloro-2-methylpyridine

生成物 1

HCID 202358511-[2-(2-Methyl-4-pyridinylamino)benzoyl]piperidine収率 9.8%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 18.2 g of 1-(2-aminobenzoyl)piperidine and 12.2 g of 2-methyl-4-chloropyridine in 5.0 ml of acetic acid was heated at reflux for six hours and then kept at room temperature overnight. The reaction mixture was concentrated in vacuo, and the residue treated with dilute acid to pH 2 and extracted with methylene dichloride. The aqueous layer was made basic with potassium carbonate and extracted with chloroform. Further work-up of this solution afforded 2.58 g of 1-[2-(2-methyl-4-pyridinylamino)benzoyl]piperidine, m.p. 93°-95° C. when recrystallized from ethyl acetate--ether--hexane.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for six hours
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. additionthe residue treated
  5. additionwith dilute acid to pH 2
  6. extractionextracted with methylene dichloride
  7. extractionextracted with chloroform

出典と根拠

ORDレコード
ord-3a247d4932c8499db59017a7574b9655
出典データセット
uspto-grants-1986_09
特許番号
US04610991

関連ノート

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