Sodium metaborate → 1-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol

HRID 64898

反応式

HRID 64898 の反応式
B([O-])=O.[Na+].[CH2:5]([O:8][C:9]1[CH:27]=[CH:26][C:12]([O:13][CH:14]([N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)[C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:11][CH:10]=1)[CH:6]=[CH2:7]>CO>[CH2:5]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]([N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)[CH:15]([OH:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:26][CH:27]=1)[CH:6]=[CH2:7]

参加物

4

反応物 2

HCID 145326Sodium metaborateHCID 133686231-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone

生成物 1

HCID 133686241-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol収率 97.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1 g (0.027 mole) of sodium boranate is added in portions to 7.2 g (0.023 mole) of 1-(4-allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone (Example 1) in 80 ml of methanol at 20° C., while stirring. The mixture is subsequently stirred for 1 hour and is then concentrated in vacuo by distilling off the solvent. The residue is partitioned between methylene chloride and water. The organic phase is separated off, dried over sodium sulphate and concentrated in vacuo. 7 g (97.2% of theory) of 1-(4-allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol of melting point 85° C. are obtained.

後処理

  1. stirringThe mixture is subsequently stirred for 1 hour
  2. concentrationis then concentrated in vacuo
  3. distillationby distilling off the solvent
  4. customThe residue is partitioned between methylene chloride and water
  5. customThe organic phase is separated off
  6. dry with materialdried over sodium sulphate
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-bf3ac941a9f04771a1236503f1887025
出典データセット
uspto-grants-1986_09
特許番号
US04610996

関連ノート

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