Methylamine → 1-(benzo[b]thiophen-7-yl)-N-methylmethanamine

HRID 649004ノート

反応式

HRID 649004 の反応式
Br[CH2:2][C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH3:12][NH2:13]>ClCCl.C(O)C>[S:9]1[CH:10]=[CH:11][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([CH2:2][NH:13][CH3:12])[C:8]1=2

参加物

5

反応物 2

HCID 6329MethylamineHCID 107517617-(Bromomethyl)-1-benzothiophene

生成物 1

HCID 107024531-(benzo[b]thiophen-7-yl)-N-methylmethanamine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

7-Bromomethylbenzo[b]thiophene is dissolved in dichloromethane, added to 40 ml of a 33% solution of methylamine in ethanol and allowed to stand overnight. The resulting mixture is concentrated and the residue taken up in dichloromethane and extracted with 2N HCl. The aqueous phase is made strongly basic with NaOH and shaken with dichloromethane. The organic phase is dried with potassium carbonate, concentrated by evaporation and the residue vacuum distilled to produce the title product as an oil. B.p.=103°/1.3 mbar.

後処理

  1. concentrationThe resulting mixture is concentrated
  2. extractionextracted with 2N HCl
  3. dry with materialThe organic phase is dried with potassium carbonate
  4. concentrationconcentrated by evaporation
  5. distillationthe residue vacuum distilled

出典と根拠

ORDレコード
ord-8aaa18b0b5a44412abfae50677459ff9
出典データセット
uspto-grants-1988_04
特許番号
US04737516

反応ノート

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