Ammonia → HCID 20142073、化合物
反応式
[NH3:1].[Cl:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([O:13][C:14]3[CH:27]=[CH:26][C:17]([O:18][CH:19]([CH3:25])[C:20](OCC)=[O:21])=[CH:16][CH:15]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1>CC(C)=O>[Cl:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([O:13][C:14]3[CH:27]=[CH:26][C:17]([O:18][CH:19]([CH3:25])[C:20]([NH2:1])=[O:21])=[CH:16][CH:15]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
Concentrated ammonia was added at 20° C. to a solution of ethyl 2-[4-(7-chloroquinolin-3-yloxy)phenoxy]propionate (3.0 g) (see Example 5) in acetone (50 ml) until the mixture just began to turn cloudy. The mixture was then heated at 60° C. for 8 hours and allowed to cool and stand overnight. Colourless crystals (1.5 g) 2-[4-(7-chloroquinolin-3-yloxy)phenoxy]propionamide were collected by filtration. The compound was characterised by its proton magnetic resonance spectrum. (Table 3).