Methyl 6-amino-5-nitropyridine-3-carboxylate → Methyl 5,6-diaminopyridine-3-carboxylate

HRID 649179ノート

反応式

HRID 649179 の反応式
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1>CO.[C].[Pd]>[NH2:12][C:11]1[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

参加物

4

反応物 1

HCID 13768248Methyl 6-amino-5-nitropyridine-3-carboxylate

生成物 1

HCID 9920476Methyl 5,6-diaminopyridine-3-carboxylate

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

1 Gram of methyl 6-amino-5-nitronicotinate was dissolved in 10 ml of methanol. To this solution was added 0.1 g of 5%-palladium-carbon, then hydrogen gas was absorbed at room temperature under a normal pressure. The reaction was stopped when the stoichiometric amount of hydrogen was absorbed. The catalyst was removed from the reaction mixture by filtration, and the solvent was removed by evaporation. The residue thus obtained was recrystallized from ethanol to yield 0.8 g of methyl 5,6-diaminonicotinate in the form of yellow needle-like crystals. Melting point: 154°-155° C.

後処理

  1. customhydrogen gas was absorbed at room temperature under a normal pressure
  2. customwas absorbed
  3. customThe catalyst was removed from the reaction mixture by filtration
  4. customthe solvent was removed by evaporation
  5. customThe residue thus obtained
  6. customwas recrystallized from ethanol

出典と根拠

ORDレコード
ord-0dd86a8cbda34bd3b0441db805319887
出典データセット
uspto-grants-1988_04
特許番号
US04738970

反応ノート

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