Hydrochloric Acid → 3,4-Dihydro-2-(3,4-dimethoxyphenyl)-4-methyl-2-[4-(N-methyl-3,4,5-trimethoxyphenethylamino)butyl]-3-oxo-2H-1,4-benzothiazine oxalate

関与物質

反応手順

To a stirred solution of 2-(4-bromobutyl)-3,4-dihydro-2-(3,4-dimethoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (1.5 g, compound No. 32) in dimethylformamide (20 ml), sodium carbonate (0.7 g) and N-methyl-3,4,5-trimethoxyphenethylamine (1.1 g) are added, and the mixture is stirred for 1 hour at 80°-90° C. The mixture is poured into a mixture of chloroform and 1N hydrochloric acid, and the organic layer is concentrated in vacuo. The residue is treated by the similar method as in Example 24 to give 1.5 g (65.8%) of the titled compound.

情報源と証拠