Ammonia → Ciobutide
反応式
[C:1]([C:3]([CH2:15][CH3:16])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:4](OCC)=[O:5])#[N:2].[NH3:17]>C(O)C>[C:1]([C:3]([CH2:15][CH3:16])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:4]([NH2:17])=[O:5])#[N:2]参加物
4
実験手順
A 10% solution of ethyl 2-cyano-2-ethyl-2-phenylacetate in ethanol is saturated with ammonia under cooling. The reaction mixture is allowed to stand at 5° C. for 96 hours, thereafter the solvent and the excess of ammonia are removed, and the product is filtered off. 2-Cyano-2-ethyl-2-phenylacetic acid amide is obtained with a yield of 80%; m.p.: 116.5°-117° C.
後処理
- temperatureunder cooling
- customthe solvent and the excess of ammonia are removed
- filtrationthe product is filtered off
出典と根拠
- ORDレコード
- ord-f901cee003404032a021404e55f78111
- 出典データセット
- uspto-grants-1988_04
- 特許番号
- US04740228
反応ノート
読み込み中…