Morpholine → HCID 14076582、化合物
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([C:9]([C:19]#[N:20])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:10](Cl)=[O:11])[CH3:8]>C(OCC)C>[C:19]([C:9]([CH2:7][CH3:8])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:10]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:11])#[N:20]参加物
4
実験手順
8.7 g (0.1 mole) of morpholine are dissolved in 20 ml of dry diethyl ether, and a solution of 10.5 g (0.05 mole) of 2-ethyl-2-phenyl-cyanoacetyl chloride in 20 ml of dry diethyl ether are added dropwise under cooling with ice (at a temperature below 10° C.). The reaction mixture is refluxed for 30 minutes, then cooled and washed with water. The organic phase is separated, washed in succession with 5% aqueous sodium carbonate solution, 2n aqueous hydrochloric acid and water, dried over magnesium sulfate, and evaporated. 11.4 g (89%) of 2-cyano-2-ethyl-2-phenylacetic acid morpholide are obtained; m.p.: 88°-90° C.