2-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl ester → 3-[[(4-Cyano-6-methoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylic acid, methyl ester

HRID 649438

反応式

HRID 649438 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[C:12]([C:16]1[S:17][CH:18]=[CH:19][C:20]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22])([O:14][CH3:15])=[O:13]>C(Cl)Cl>[C:8]([C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:25]([NH:24][S:21]([C:20]2[CH:19]=[CH:18][S:17][C:16]=2[C:12]([O:14][CH3:15])=[O:13])(=[O:22])=[O:23])=[O:26])[N:7]=1)#[N:9]

参加物

4

反応物 2

HCID 1572962-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl esterHCID 141292502-Amino-6-methoxypyrimidine-4-carbonitrile

生成物 1

HCID 141292513-[[(4-Cyano-6-methoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylic acid, methyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Amino-4-cyano-6-methoxypyrimidine, 0.1 g, was mixed with 2-carbomethoxythiophene-3-sulfonyl isocyanate, 0.165 g, in 10 ml of methylene chloride. The reaction mixture was stirred at room temperature overnight. The reaction mixture was stripped to yield 0.19 g of the title compound as a solid, m.p. 89°-92° C. (dec). NMR (CDCl3): δ6.89 (s, 3H), 4.20 (s, 3H), 6.83 (s, 1H), 7.59 (d, 1H), 7.80 (d, 1H).

出典と根拠

ORDレコード
ord-d474613647f64916ae1c47abf4f4ae76
出典データセット
uspto-grants-1988_04
特許番号
US04740229

関連ノート

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