1H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl- → HCID 178462747、化合物

HRID 649493

反応式

HRID 649493 の反応式
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N:6]([CH2:10][CH3:11])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.Cl[CH2:16][CH2:17][NH:18][S:19]([CH3:22])(=[O:21])=[O:20]>C1(OC)C=CC=CC=1>[Cl-:1].[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N+:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]([CH2:16][CH2:17][NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 767171H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl-HCID 89092N-(2-Chloroethyl)methanesulphonamide

生成物 1

HCID 178462747HCID 178462747、化合物

試薬・触媒・溶媒 1

HCID 7519Anisole溶媒

反応条件

温度
150 °C

実験手順

22.9 g (0.1 mol) of 5,6-dichloro-1-ethyl-2-methylbenzoimidazole and 23.6 g (0.15 mol) of N-(2-chloroethyl)methanesulfonamide were put into a 200-ml three-necked flask equipped with a stirrer and heated with stirring for 2 hours on an oil bath which had been heated to a temperature of 150° C. Then, 20 ml of anisole was added to the mixture. The mixture was then allowed to cool to room temperature with stirring. The resulting crystals were filtered off, washed with acetone and isopropanol, and dried.

後処理

  1. customequipped with a stirrer
  2. temperatureheated
  3. temperatureto cool to room temperature
  4. stirringwith stirring
  5. filtrationThe resulting crystals were filtered off
  6. washwashed with acetone and isopropanol
  7. customdried

出典と根拠

ORDレコード
ord-a56c3e55fb414f519a9b494eeb94be17
出典データセット
uspto-grants-1988_04
特許番号
US04740455

関連ノート

読み込み中…