Anisole → HCID 178462746、化合物

HRID 649498

反応式

HRID 649498 の反応式
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N:6]([CH2:10][CH3:11])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.[Br:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[CH2:21][CH2:20][C:19]1=[O:24].C1(OC)C=CC=CC=1>C(OCC)(=O)C>[Br-:15].[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N+:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]([CH2:16][CH2:17][N:18]3[C:22](=[O:23])[CH2:21][CH2:20][C:19]3=[O:24])[C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 7519AnisoleHCID 767171H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl-HCID 135613951-(2-Bromoethyl)pyrrolidine-2,5-dione

生成物 1

HCID 178462746HCID 178462746、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
130 °C

実験手順

11.5 g of 5,6-dichloro-1-ethyl-2-methylbenzoimidazole and 20.6 g of N-(2-bromoethyl)succinimide were put into a 200-ml three-necked flask equipped with a stirrer and a reflux condenser and heated for 2 hours on an oil bath which has been heated to a temperature of 130° C. 10 ml of anisole was added to the mixture. The admixture was then allowed to stand for cooling. 50 ml of ethyl acetate was added to the admixture. The admixture was then refluxed for 30 minutes. After being allowed to cool to room temperature, the resulting crystal was filtered off, washed with acetone, and then dried at a temperature of 50° C. for 5 hours. Yield: 18.7 g (86%).

後処理

  1. customequipped with a stirrer and a reflux condenser
  2. temperatureheated for 2 hours on an oil bath which
  3. temperaturefor cooling
  4. temperatureThe admixture was then refluxed for 30 minutes
  5. temperatureto cool to room temperature
  6. filtrationthe resulting crystal was filtered off
  7. washwashed with acetone
  8. customdried at a temperature of 50° C. for 5 hours

出典と根拠

ORDレコード
ord-86e8fa36df7b4279be13c2ee187f9e9b
出典データセット
uspto-grants-1988_04
特許番号
US04740455

関連ノート

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