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1,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridine → 2-[4-(3-Indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridine | HCID 413282 | — |
| 反応物 | 3-(4-Chlorobutyl)indole | HCID 13327011 | — |
| 反応物 | 3-(4-Bromobutyl)-1h-indole | HCID 14201179 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-[4-(3-Indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine | HCID 13747486 | — |
反応手順
A solution of 20.8 g of 3-(4-chlorobutyl)indole [or 25.2 g of 3-(4-bromobutyl)indole] and 18.9 g of 1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine in 100 ml of acetonitrile is stirred at 20° for 12 hours. The usual working up is carried out, and 2-[4-(3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine ("A"), m.p. 113°-115° is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04740602 |
| 出典データセット | uspto-grants-1988_04 |
| ORD ID | ord-f801927f389c460fae4d178df9f4bbd8 |
| 出典メモ | uspto-grants-1988_04 |